PrEP or pre-exposure prophylaxis involves HIV negative people taking HIV medication called Truvada as a method of helping to prevent HIV infection. 

Recent research has shown that if taken correctly, Truvada is highly effective at preventing HIV infection.

It does not protect against any other STI, only HIV. You need to take other precautions in addition to PrEP to protect yourself from all other STIs. We recommend regular STI testing if you are on PrEP. You should have an HIV test every 3 month.

How to take PrEP

There are 2 ways of taking PrEP (based on 2 European studies):

PROUD study1

  • One tablet every 24 hours.

IPERGAY trial2

  • Event-based dosing for a single sex act comprises two tablets 2–24 hours before sex, one tablet 24 hours (22–26 hours) after the first dose, and another tablet 48 hours (46–50 hours) after the first dose.
  • This regimen is not recommended for vaginal sex.

Unfortunately, the cost of PrEP medicines is not currently covered by the NHS. However we can provide free advice and monitoring in any of our routine sexual health appointments.

NHS PrEP trial

All Northern Sexual Health sites have now gone live for recruitment into the Impact PrEP trial. Please note there are limited places available for the service and dedicated waiting lists already in place across the sites. To be added to the waiting list or to find out if there are likely to still be places available please contact the following numbers.

Hathersage : 0161 701 1504 

Stockport : 0161 204 5884

Tameside : 0161 342 7101

Trafford : 0161 241 7582

Withington : 0161 217 3318

North Manchester : 0161 918 4263

Please note due to longstanding overwhelming demand, places can not be guaranteed onto this trial. Please bear with staff as they try to get recruitment for the trial off the ground. 


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